基于质谱的蛋白质从头测序在抗体、新抗原、未知物种蛋白测序中有重要应用。现有从头测序技术受制于质谱信息的缺失，测序覆盖度和准确性较低。中科院数学院与合作单位基于镜像酶实验策略和多个创新性人工智能及统计方法研发了自主知识产权的蛋白质从头测序软件系统DiNovo，将高可靠序列覆盖度提高了两倍，并在国内多家单位成功试用。相关成果发表在《自然通讯》（Nature Communications）上，并获得专利授权和软件著作权。
Publication:Nature Communications
https://doi.org/10.1038/s41467-026-70224-6
Author:Zixuan Cao,State Key Laboratory of Mathematical Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China.
These authors contributed equally: Zixuan Cao, Xueli Peng, Di Zhang, Piyu Zhou, Li Kang.
Xueli Peng,State Key Laboratory of Mathematical Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China,University of Chinese Academy of Sciences, Beijing, China.
These authors contributed equally: Zixuan Cao, Xueli Peng, Di Zhang, Piyu Zhou, Li Kang.
Di Zhang, School of Computer Science and Technology, Shandong University of Technology, Zibo, China.
These authors contributed equally: Zixuan Cao, Xueli Peng, Di Zhang, Piyu Zhou, Li Kang.
Piyu Zhou,State Key Laboratory of Mathematical Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China.
These authors contributed equally: Zixuan Cao, Xueli Peng, Di Zhang, Piyu Zhou, Li Kang.
Li Kang. State Key Laboratory ofMedical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics and Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China, Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, China.
These authors contributed equally: Zixuan Cao, Xueli Peng, Di Zhang, Piyu Zhou, Li Kang.
Hao Chi,University of Chinese Academy of Sciences, Beijing, China,Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.
Ruitao Wu,School of Computer Science and Technology, Shandong University of Technology, Zibo, China
Zhiyuan Cheng,State Key Laboratory of Mathematical Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China,University of Chinese Academy of Sciences, Beijing, China.
Yao Zhang,State Key Laboratory ofMedical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics and Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Jiaxing Dai,State Key Laboratory ofMedical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics and Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Yanchang Li,State Key Laboratory ofMedical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics and Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Lijin Yao, School of Computer Science and Technology, Shandong University of Technology, Zibo, China.
Xinming Li, School of Computer Science and Technology, Shandong University of Technology, Zibo, China.
Yaoyu He,State Key Laboratory of Mathematical Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China.
Jinghan Yang, State Key Laboratory of Mathematical Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China.
Haipeng Wang, School of Computer Science and Technology, Shandong University of Technology, Zibo, China.
e-mail: hpwang@sdut.edu.cn
Ping Xu, State Key Laboratory ofMedical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics and Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, China.
e-mail: xuping_bprc@126.com
Yan Fu,State Key Laboratory of Mathematical Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China.
e-mail: yfu@amss.ac.cn
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